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The rule with any allergy restriction essay

Czarnecka-Operacz Find articles by Magdalena M. They not only cause significant deterioration in the quality of life of patients but also lead to significant absenteeism and reduced productivity, resulting in very high costs for society. Effective and safe treatment of allergic diseases is therefore one of the main challenges for public health and should be carried out by all the specialists in family medicine, internists and paediatricians in collaboration with allergists, otorhinolaryngologists and dermatologists.

Antihistamines are most commonly used in the treatment of allergies. Several dozen drugs are available on the pharmaceutical market, and their generic forms are advertised widely as very effective drugs for the treatment of allergic diseases.

What is the truth? What are the data from clinical trials and observational studies?


Are all drugs equally effective and safe for the patient? According to a panel of experts representing various fields of medicine, inappropriate treatment of allergies can be very risky for patients, and seemingly equally acting medications may differ greatly.

Therefore, a panel of experts gathered the latest data from the entire scientific literature and analysed the latest standards and recommendations prepared by scientific societies. This paper provides a summary of these studies and highlights the rule with any allergy restriction essay importance for the patient of the proper choice of drug to treat his allergies.

In the last few decades the incidence of allergic diseases has grown to epidemic status. Despite this huge number of patients, these data are frequently underestimated, since allergic diseases are generally believed to be trivial and non-hazardous. However, it has already been proven that allergic rhinitis, asthma and urticaria are associated with a significant socioeconomic burden all over the world — regardless of region, development level and financial status.

The total cost of allergic diseases brings both reduced quality of life and also direct costs of drugs and health services as well as indirect social costs such as the absence from work; it also decreases productivity and concentration and generates learning disorders and concomitant diseases. As allergic diseases occur mainly in the young population which supports the senior populationtheir consequences are much more costly than those of diabetes, coronary heart disease or myocardial infarctions.

  1. The following rules may be found in one or another food theory.
  2. I was eventually saved from the doom of eternal health food addiction through three fortuitous events. After a year or so of this self imposed regime, I felt light, clear headed, energetic, strong and self-righteous.
  3. Furthermore, intrusive thoughts of sprouts came between me and good conversation.

In the USA alone, the costs of allergic rhinitis morbidity are estimated at over 25 billion dollars per year, of which approximately a half consists of indirect costs, resulting from insufficient disease control. Efficient therapy of the most common allergic diseases is based mainly on oral antihistamines which are administered simply and, as a result, have the best compliance among the drugs recommended for the treatment of allergic rhinitis.

Histamine plays an important role in human physiology, influencing immunoregulation of the acute and chronic inflammatory response through 4 different types of receptors, called H1, H2, H3, and H4. Apart from all histaminic receptors they also block muscarinic, adrenergic or adrenoreceptors and dopaminergic receptors, causing cardiovascular, urinary and gastrointestinal adverse reactions.

The role and choice criteria of antihistamines in allergy management – expert opinion

High lipophilicity and consequently easy crossing of the blood-brain barrier additionally intensify the most dangerous adverse events from the central nervous system, including drowsiness, decreased concentration, vigilance and psychomotor efficiency as well as reduced ability to learn and memorize, which is not related to sedation.

However, in histamine-dependent allergic diseases the most important role is played by the H1 receptor, whose stimulation by histamine results in e. Therefore, the discovery of compounds the rule with any allergy restriction essay acting on H1 receptors, currently called second generation drugs, could be considered the greatest breakthrough during more than 70 years of the history of antihistamines Figure 1.

On top of the high efficacy, the most important feature of these drugs is the incomparably better safety profile: Due to the selective mechanism of action, low penetration of the central nervous system CNS and lack of interaction with adrenergic, muscarinic and dopaminergic receptors, the second generation drugs are devoid of the majority if not all of the side effects mentioned above; however, some of them could cause other serious adverse reactions, including body mass gain, inter-drug interactions or potentially life-threatening cardiotoxicity in the majority of countries, these preparations have been withdrawn from the market Figure 2.

  • Some commune members firmly believed that vital substances clinging just under the skins must be preserved at all costs;
  • I had been seduced by righteous eating;
  • Others felt that a host of evil pollutants adhered to the same surfaces that needed to be vigorously scrubbed away;
  • It slows the digestion, he explained, clogs the metabolism, plugs the arteries, dampens the digestive fire, and causes mucous, respiratory diseases and cancer.

Due to selective antagonism with H1 receptors, these drugs are highly effective in reduction of allergic rhinitis and urticaria symptoms, and the wide therapeutic index makes it possible to use them in very high doses without any concerns related to overdosing toxicity, which with the first generation drugs could lead to consciousness disturbances, coma, respiratory distress, and even death.