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A clinical description of the genetic disorder disease sickle cell anemia

Sickle Cell Disease

Sickle cell anemia is a blood disease that affects red blood cells. Normal red blood cells are round. In people with sickle cell anemia, hemoglobin — a substance in red blood cells — becomes defective and causes the red blood cells to change shape. The faulty hemoglobin is called hemoglobin S, HgbS and it replaces normal hemoglobin called: Over time, the red blood cells become rigid and shaped like crescent moons or sickles.

Sickle Cell Anemia

The sickle-shaped red blood cells: Clog blood vessels, causing episodes of pain and cutting off oxygen to tissues and organs. Get trapped in the spleen an organ that gets rid of old cells where they are destroyed.

Sickle Cell Disease (Sickle Cell Anemia)

The body cannot replace the lost cells fast enough. As a result, the body has too few red blood cells, a condition known as anemia. Sickle cell anemia is a serious disease that can require frequent hospital stays. Children and young adults can die from the disease.

  1. Hydroxyurea can be suppressive to the bone marrow. The pain varies in intensity and can last for a few hours to a few weeks.
  2. Liver enlargement hepatomegaly occurs as it becomes congested with red blood cells as well.
  3. People with sickle cell anemia can develop high blood pressure in their lungs pulmonary hypertension. The patient with suspected acute chest syndrome should be admitted to the hospital with worsening A-a gradient an indication for ICU admission.

Who gets the disease? In the United States, the disease occurs most often among African-Americans in about 1 of every 400 African-American births and among Hispanics of Caribbean ancestry 1 in every 1,000 to 1,400 Hispanic-American children.

Throughout the world, the disease is also found among people of Arabian, Greek, Italian, Sardinian, Turkish, Maltese, and southern Asian ancestry. Is there a difference between sickle cell anemia and sickle cell trait? A person can have a mixture of normal and faulty hemoglobin in their red blood cells without having sickle cell disease. This condition is called "sickle cell trait.

  1. The sickle-shaped red blood cells.
  2. Impairment of the normal function of the spleen increases the tendency to become infected with bacteria.
  3. Antibiotics to try to prevent infections in younger children Pain relievers for acute or chronic pain Hydroxyurea, a medicine that has been shown to reduce or prevent several SCD complications. It might require emergency medical treatment with antibiotics and other treatments.
  4. All states now test newborns as part of their screening programs, so treatment can begin early. Aseptic necrosis is also referred to as osteonecrosis.
  5. Chronic deprivation of oxygen-rich blood can damage nerves and organs in your body, including your kidneys, liver and spleen.

One in 12 African-Americans in the United States has sickle cell trait. It's important to remember that people with sickle cell trait do not have sickle cell disease. They also usually do not develop sickle cell disease, except in unusual circumstances. However, people with sickle cell trait can genetically pass the trait to their children. If two people with sickle cell trait have children together, there is a 1 in 4 chance that their children will have sickle cell anemia.

What are the chances that my child will be born with sickle cell anemia or sickle cell trait? How does a person get sickle cell anemia? People with sickle cell anemia inherit the disease, which means that the disease is passed on to them by their parents as part of their genetic makeup.

Sickle cell disease

Parents cannot give sickle cell anemia to their children unless they both have the faulty hemoglobin in their red blood cells. What are the symptoms and complications of sickle cell anemia? Periods of pain that can last a few hours to a few days. Swelling in hands and feet.

Joint pain that resembles arthritis.