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Phosphocreatine resynthesis is not affected by creatine loading

Canadian Journal of Applied Physiology, 2001, 26 S1: Recently, research has shifted from performance evaluation towards elucidating the mechanisms underlying enhanced muscle functional capacity after creatine supplementation. In this review, we attempt to summarise recent advances in the understanding of potential mechanisms of action of creatine supplementation at the level of skeletal muscle cells. Furthermore, evidence is accumulating to suggest that creatine supplementation can beneficially impact on muscle protein and glycogen synthesis.

Thus, muscle hypertrophy and glycogen supercompensation a1'e candidate factors to explain the ergogenic potential of creatine ingestion. Additional issues discussed in this review are the fibre-type specificity of muscle creatine metabolism, the identification of responders versus non-responders to creatine intake, and the scientific background concerning potential side effects of creatine supplementation.

Time course of changes in markers of myogenesis in overloaded rat skeletal muscles. Stimulation of insulin secretion by guanidinoacetic acid and other guanidine derivatives. Elevated muscle glycogen and anaerobic energy production during exhaustive exercise in man.

Hemodynamic actions of insulin. Contribution of satellite cells to IGF-I induced hypertrophy of skeletal muscle. Effects of oral creatine supplementation on muscular strength and body composition. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Impaired phosphocreatine hydrolysis in exercise in myophosphorylase deficiency determined by 31P MRS.

The role of the phosphocreatine energy shuttle in exercise and muscle hypertrophy. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Metabolic fluctuation during a muscle contraction cycle. Oxidative capacity and ageing in human muscle. Metabolic responses of type I and type II muscle fibers during repeated bouts of maximal exercise in humans. Dietary creatine monohydrate supplementation increases satellite cell mitotic activity during compensatory hypertrophy.

Mitochondrial creatine kinase in contact sites: Muscle relaxation and sarcoplasmic reticulum function in different muscle types. Creatine supplementation increases renal disease progression in Han: Aging of skeletal muscle: A 12-yr longitudinal study. A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women. A reexamination of the effects of phosphocreatine resynthesis is not affected by creatine loading on muscle protein synthesis in tissue culture.

Human muscle metabolism during intermittent maximal exercise. Relaxation of vertebrate skeletal muscle. A synthesis of the biochemical and physiological approaches. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis.

Phosphocreatine resynthesis is not affected by creatine loading.

Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Guimbal C, Kilimann MW. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Insulin effect on creatine transport in skeletal muscle. Herzog W, Leonard TR. Depression of cat soleus forces following isokinetic shortening.

Opposite actions of caffeine and creatine on muscle relaxation time in humans. Oral creatine supplementation facilitates rehabilitation of muscle disuse atrophy and alters expression of muscle myogenic factors.

Creatine and creatine metabolism in the normal adult studied with the aid of isotopic nitrogen. Does muscle creatine phosphokinase have access to the total pool of phosphocreatine plus creatine? Selective accumulation of MyoD and myogenin in fast and slow skeletal muscle is controlled by innervation and hormones.

Breakdown and resynthesis of phosphorylcreatine and adenosine triphosphate in connection with muscular work in man. Muscle creatine loading in men. Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle. Creatine and the control of myosin synthesis in differentiating skeletal muscle. Specificity of creatine in the control of muscle protein synthesis. The creatinemediated increase in muscle phosphocreatine resynthesis during recovery from maximal exercise in humans is associated with increased mitochondrial acetyl group utilisation.

Juhn MS, Tamopolsky M. Oral creatine supplementation and athletic performance: Why do cells need phosphocreatine and a phosphocreatine shuttle? Efficiency of energy conversion from metabolic substrates to ATP and mechanical and chemiosmotic energy. Skeletal muscle oxidative capacity in young and older women and men. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

Interstitial nephritis in a patient taking creatine. Effect of insulin on the uptake of creatine- 1- 14C by skeletal muscle in normal and X-irradiated rats.

Effects of creatine supplementation on body composition, strength, and sprint performance. Creatine supplementation - part II: In vivo magnetic resonance spectroscopy.

Canadian Journal of Applied Physiology

Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. Lougbna PT, Brownson C. Two myogenic regulatory factors phosphocreatine resynthesis is not affected by creatine loading exhibit muscle-specific responses to disuse and passive stretch in adult rats. Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume.

Effects of ADP on sarcoplasmic reticulum function in mechanically skinned skeletal muscle fibres of the rat. Glucagon-releasing activity of guanidine compounds in mouse pancreatic islets.

Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats. Muscle metabolism in older subjects using 31p magnetic resonance spectroscopy.

The effects of dietary creatine supplements on the contractile properties of rat soleus and extensor digitorum longus muscles. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Inhibition of rate of tumor growth by creatine and cyclocreatine.

Myogenin, MyoD, and myosin expression after pharmacologically and surgically induced hypertrophy. Effect of aging on energy-rich phosphagens in human skeletal muscles.

Creatine transporter protein content, localization and gene expression in rat skeletal muscle. Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Muscle glycogen supercompensation is enhanced by prior creatine supplementation.

Impaired insulin-induced glucose utilization and glycogen synthase activity, but intact GSK3 alpha deactivation in patients with chronic high muscle glycogen stores.

The regulation of total creatine content in a myoblast cell line. Short-term creatine supplementation does not alter the hormonal response to resistance training.

Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization.

Clinical pharmacology of the dietary supplement creatine monohydrate. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. Effect of short-term creatine supplementation on renal responses in men.

Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Adverse effects of creatine supplementation: Renal dysfunction accompanying oral creatine supplements. Hemodynamic actions of insulin in rat skeletal muscle: Effects of 30 days of creatine ingestion in older men. Adaptation of muscle to creatine depletion: Influence of reduced glycogen level on glycogenolysis during short-term stimulation in man.

Creatine reduces human muscle PCr and pH decrements and Pi accumulation during low-intensity exercise. Creatine enhances oxygen uptake and performance during alternating intensity exercise. Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS.

  • In this review, we attempt to summarise recent advances in the understanding of potential mechanisms of action of creatine supplementation at the level of skeletal muscle cells;
  • Oral creatine supplementation facilitates rehabilitation of muscle disuse atrophy and alters expression of muscle myogenic factors;
  • Results of this study showed that the creatine users outperformed the placebo group in 100 meter sprinting and vertical jumping;
  • Creatine supplementation increases strength, power, and total work with a greater effect in trained versus untrained individuals;
  • Two myogenic regulatory factors transcripts exhibit muscle-specific responses to disuse and passive stretch in adult rats.

Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle.